Modafinil

Modafinil Help With Narcolepsy

Stimulants are the primary medication to help people with narcolepsy stay awake during the day. The two most commonly prescribed medications are modafinil (Provigil) and armodafinil (Nuvigil). Other medications used include soriamfetol and pitolisant.

Modafinil Australia is a very effective wake-promoting drug and it doesn’t have the negative side effects of older stimulants. It’s available by prescription only and should be taken only as directed.

Dosage

Modafinil is an oral medication used to improve wakefulness in adults with excessive sleepiness associated with narcolepsy, shift work disorder, or obstructive sleep apnea (in addition to treatment of the underlying obstruction).

It works by enhancing the activity of noradrenergic and dopaminergic (specifically, the dopamine transporter) systems. It also interacts with GABAergic, histaminergic, and glutamatergic systems in a nonselective manner.

Modafinil has been shown to promote wakefulness in narcolepsy patients through all parts of the waking day and is effective for all types of narcolepsy naps, including cataplexy. It has also been show to reduce fatigue and improve mood, as well as increase concentration and alertness.

In narcolepsy and obstructive sleep apnea studies, patients were randomly assigned to either 200 mg of modafinil once daily or 400 mg split doses administered in the morning (0700 hours) or midday (1200 hours).

Morning and noon dosages were equally effective in promoting wakefulness through all parts of the waking day. Patients were titrate to the target dose over 3 weeks. Modalert 200 mg was well tolerated compared to placebo, with headache (34% vs 23%, respectively), nausea, and infection being the most common adverse events.

Modafinil may cause an increase in heart rate. This can be avoid by starting at a low dosage and slowly increasing it over time. It can also cause high blood pressure, so it’s important to monitor your blood pressure closely.

Side effects

Modafinil is an effective wake-promoting agent that improves alertness in patients with excessive sleepiness (hypersomnolence) associated with shift work sleep disorder, obstructive sleep apnea, or narcolepsy.

It is well tolerated in these patient groups, with headache, nausea, and infection being the most common adverse events. Its use is complementary to existing therapies and does not have the potential for abuse or addiction that is associate with other stimulant drugs.

Several 3-week randomized, double-blind, placebo-controlled studies have evaluated the safety and tolerability of modafinil in patients with SWSD, OSA, or narcolepsy. These studies included a 1-week placebo run-in period and were compare to a daily 200-mg dose of modafinil.

These studies were similar to each other and showed that the 200-mg daily dose of modafinil was effective in maintaining wakefulness for the entire waking day in patients with narcolepsy. 

The addition of a 200-mg midday dose was also well tolerated and promoted wakefulness in patients with narcolepsy who experienced late afternoon/evening sleepiness despite receiving a once-daily 200-mg modafinil regimen.

Modafinil undergoes hepatic metabolism and approximately 80% of the dose is recovere in the urine as metabolites. Modafinil is eliminat from the body in about 15 hours. Severe renal and hepatic impairment may result in increased steady-state drug concentrations and altered pharmacokinetics.

Schedule

Modafinil is a first-choice medication for narcolepsy and obstructive sleep apnea. It is typically take once per day in the morning for these conditions. Studies have shown that higher doses, such as 400 mg daily, may also be beneficial for these conditions.

Studies have shown that splitting a daily dose into two or more doses is also effective in promoting wakefulness. This is particularly useful for patients with shift work disorder, who tend to have irregular sleep-wake schedules. In studies of SWSD, modafinil was administer 30 to 60 minutes before each regularly scheduled night shift for 12 weeks.

It is important to remember that even though the studies mentioned in this article show that larger dosages of 200 modafinil pills can be beneficial for narcolepsy and other sleep disorders, you should only take as much as your doctor recommends. Your doctor will start you on a low dosage and increase it over time to find the right balance that works for you.

It is also important to avoid caffeine, which can increase the side effects of this drug. You should check the ingredients of any nonprescription products you are taking, including cough-and-cold products and diet aids, to ensure they do not contain any caffeine. In addition, breastfeeding women should avoid this medication since it is excrete into breast milk and can harm infants.

Safety

In two nine-week, large-scale, double-blind clinical trials, patients with narcolepsy receiving either 200 or 400 mg of modafinil once daily showed significantly better results in standard measurements of wakefulness than those on placebo. This improvement was comparable to that seen with methylphenidate or d-amphetamine.

Unlike amphetamine-like stimulants, this medicine has not been show to cause addiction. It has been show to have pharmacological activity in several neurotransmitter systems, including the noradrenergic, dopaminergic (specifically the dopamine transporter), GABAergic, glutamatergic, histaminergic, and hypocretin systems.

This medication should not be take by pregnant women. It may harm an unborn baby. If a woman becomes pregnant while taking this drug, she should tell her doctor immediately. It is also not know whether this drug passes into breast milk. If you are a nursing mother, it is best to not take this drug.

This medication should be store at room temperature and away from excess heat and moisture, as well as out of the reach of children. Keep the bottle closed tightly when not in use. Ask your pharmacist about the proper disposal of unused or outdated medication.

This medication is take orally and usually taken once a day in the morning. For shift work sleep disorder, it is often take 1 hour before the start of the shift. Your doctor may change your dose or the time of day that you take this medication based on your medical condition and response to treatment.

Keep track of how many tablets you have left, and don’t take more than prescribed. Your doctor will determine the exact dosage for you. Do not share this medication with others. Teenagers and children should only use this medicine under a physician’s supervision. Read Mero Blog…

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